NAD+ Nicotinamide Adenine Dinucleotide
Product Name: NAD+ (Nicotinamide Adenine Dinucleotide)
CAS Number: 53-84-9
EINECS Number: 200-184-4
Molecular Formula: C₂₁H₂₇N₇O₁₄P₂
Molecular Weight: 663.43 g/mol
Chemical Class: Dinucleotide coenzyme / Pyridine nucleotide
Purity: ≥99.0% (HPLC)
Appearance: White to off-white crystalline powder
Solubility: Freely soluble in water; practically insoluble in ethanol, ether, and organic solvents
pH (1% aqueous solution): 3.0 – 5.0
Melting Point: Decomposes above 180°C
NAD+, Nicotinamide Adenine Dinucleotide, Coenzyme I, cellular energy, anti-aging active ingredient, DNA repair, sirtuin activator, collagen booster, skin rejuvenation, cosmetic grade NAD, mitochondrial health, skincare raw material, β-NAD+
NAD+ Nicotinamide Adenine Dinucleotide（CAS 53-84-9）
Nicotinamide Adenine Dinucleotide (NAD+), also known as Coenzyme I, is a vital coenzyme present in every living cell of the human body.
It plays a central role in cellular energy metabolism, serving as a key electron carrier in glycolysis, the Krebs cycle, and oxidative phosphorylation — the fundamental processes that generate ATP, the cellular energy currency.
Beyond energy production, NAD+ is an essential substrate for critical enzymes including sirtuins (longevity proteins), PARPs (DNA repair enzymes), and CD38, which regulate cellular aging, DNA damage repair, immune response, and metabolic homeostasis.
Key Benefits
• Cellular Energy Recharge — Boosts ATP production, revitalizing tired and aging skin cells at the mitochondrial level
• DNA Repair Support — Serves as substrate for PARP enzymes, enhancing the skin's natural DNA damage repair mechanisms
• Sirtuin Activation — Activates longevity proteins (SIRT1-SIRT7) that regulate cellular aging and promote youthful cell function
• Collagen Synthesis Boost — Supports fibroblast activity and promotes natural collagen and elastin production for firmer skin
• Powerful Antioxidant Defense — Enhances cellular antioxidant capacity, neutralizing free radicals and reducing oxidative stress
• Improves Skin Elasticity — Strengthens dermal structure, reducing sagging and improving skin firmness and bounce
• Brightens Dull Complexion — Restores cellular energy for a more radiant, glowing, and even-toned complexion
• Enhances Skin Barrier — Supports keratinocyte health and strengthens the skin's natural protective barrier function
• Promotes Cell Renewal — Accelerates epidermal cell turnover for smoother, fresher, more youthful-looking skin
• Reduces Fine Lines & Wrinkles — Visibly diminishes the appearance of fine lines and deep wrinkles with consistent use
• High Bioavailability — Cosmetic-grade formulation optimized for skin penetration and cellular uptake
• Premium Anti-Aging Ingredient — A cutting-edge, science-backed active at the forefront of modern skincare innovation
Applications
• Anti-Aging Serums & Essences (30%) — Premium anti-aging serums, rejuvenating essences, and luxury facial treatments targeting cellular aging and energy depletion
• Anti-Wrinkle Creams & Lotions (20%) — Firming creams, lifting lotions, and wrinkle-reduction moisturizers formulated with NAD+ for visible age reversal
• Eye Care Products (15%) — Under-eye serums, eye creams, and eye treatments targeting fine lines, crow's feet, and periorbital aging
• DNA Repair & Recovery (12%) — Post-sun repair serums, damage-recovery treatments, and nighttime repair formulations
• Brightening & Rejuvenating (10%) — Radiance-boosting serums, glow treatments, and complexion-perfecting products for dull, tired skin
• Barrier Repair Skincare (5%) — Barrier-strengthening moisturizers, sensitive skin repair creams, and restorative treatments
• Masks & Ampoules (5%) — Luxury sheet masks, overnight masks, and high-potency ampoule treatments with concentrated NAD+
• Body & Neck Care (2%) — Neck firming creams, décolletage treatments, and luxury body anti-aging products
• Custom Anti-Aging Systems (1%) — Professional skincare systems, clinic-grade treatments, and bespoke anti-aging formulations
Certificate Of Analysis (COA)
Test Item | Specification | Result |
Product Name | NAD+ (Nicotinamide Adenine Dinucleotide) | Complies |
INCI Name | NICOTINAMIDE ADENINE DINUCLEOTIDE | Complies |
CAS Number | 53-84-9 | Complies |
Grade | Cosmetic Grade | Complies |
Appearance | White to off-white crystalline powder | Complies |
Odor | Characteristic, slight | Complies |
Purity (HPLC) | ≥99.0% | 99.5% |
UV Identification | λmax at 259 nm | Complies |
Molecular Formula | C₂₁H₂₇N₇O₁₄P₂ | Complies |
Molecular Weight | 663.43 g/mol | Complies |
pH (1% solution) | 3.0 – 5.0 | 3.8 |
Specific Rotation | -34° to -38° (c=1%, water) | -36.2° |
Moisture Content | ≤5.0% | 2.8% |
Residue on Ignition | ≤0.1% | 0.05% |
Solubility in Water | Freely soluble | Complies |
Heavy Metals | ≤10 ppm | <5 ppm |
Arsenic (As) | ≤1 ppm | <0.5 ppm |
Lead (Pb) | ≤2 ppm | <0.5 ppm |
Mercury (Hg) | ≤1 ppm | <0.1 ppm |
Cadmium (Cd) | ≤1 ppm | <0.1 ppm |
Total Plate Count | ≤100 CFU/g | <10 CFU/g |
Yeast & Mold | ≤10 CFU/g | <10 CFU/g |
E. coli | Negative | Negative |
S. aureus | Negative | Negative |
P. aeruginosa | Negative | Negative |
Source | Biological fermentation (yeast) | Complies |
Vegan | 100% Vegan | Complies |
Storage | -20°C, dry, sealed, protected from light | Complies |
Frequently Asked Questions (FAQ)
Q1: What is the minimum order quantity (MOQ) for cosmetic-grade NAD+?
A: Our standard MOQ is 10g for cosmetic-grade NAD+. We also offer sample packs of 1g and 5g for formulation testing and evaluation. For bulk orders (1kg+), please contact our sales team for volume pricing discounts.
Q2: What purity grades are available, and which one should I choose for skincare formulations?
A: We offer cosmetic-grade NAD+ at ≥99.0% purity (HPLC), which is the standard for premium skincare products. For most anti-aging serum and cream formulations, the 99% grade is ideal. We can also provide higher purity grades (≥99.5%) upon request for ultra-premium or pharmaceutical-adjacent applications.
Q3: Is NAD+ approved for use in cosmetics globally? What are the regulatory statuses in major markets?
A: NAD+ (Nicotinamide Adenine Dinucleotide) is generally recognized as safe for cosmetic use in major global markets. It is listed in the China IECIC (Inventory of Existing Cosmetic Ingredients), approved for use in the EU under cosmetic regulations, and recognized as safe in the US under FDA cosmetic guidelines. As with any active ingredient, we recommend conducting appropriate safety testing and ensuring compliance with local regulations before market launch. Please contact our regulatory team for detailed documentation.
Q4: What is the recommended usage level of NAD+ in different cosmetic products?
A: Recommended usage levels vary by product type: 0.5%-2.0% in serums and essences, 0.3%-1.0% in creams and lotions, 0.5%-1.5% in eye care products, 1.0%-2.0% in ampoules and concentrated treatments, and 0.2%-0.5% in masks. The optimal concentration depends on your formulation goals, delivery system, and target market positioning. Our technical team can provide customized formulation guidance.
Q5: How does NAD+ compare to NMN and NR as anti-aging ingredients? What are the key differences?
A: NAD+, NMN (Nicotinamide Mononucleotide), and NR (Nicotinamide Riboside) are all related to the NAD+ pathway but differ in molecular size and mechanism. NAD+ is the final active form that cells directly use, but its larger molecular weight (663 Da) may require enhanced delivery systems for optimal skin penetration. NMN and NR are precursors that cells convert to NAD+, with smaller molecular weights that may penetrate more easily. For topical skincare, NAD+ offers the advantage of direct bioavailability when properly formulated with penetration enhancers or delivery systems. The choice depends on your formulation strategy and marketing positioning. Our R&D team can help you select the best option for your product concept.
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